Geraint undertook his Wellcome Trust Clinical Research Fellowship at the University of Birmingham (Immunoregulation of Acquired Ocular Immunobullous Disease; http://etheses.bham.ac.uk/3235/), gaining his PhD in 2012. He observed that progressive scarring of the membranes surrounding the eye (the conjunctiva) in Ocular Mucous Membrane Pemphigoid (OcMMP) occurred in the absence of clinically identifiable inflammation. He developed a novel non-invasive means of characterising ocular surface inflammatory cells in both health and disease and used this to determine that the conjunctiva was characterised by an increase in a population of cells called neutrophils and associated with progression of scarring.
He subsequently worked as a clinical lecturer at the University of Birmingham from 2012 to 2014. He combined this role with fellowship training in cornea and external disease. During his tenure he was responsible for teaching medical students and his research interests included:
- Established an international steering committee towards developing an Ocular Surface Disease Index Scoring System (OSD-ISS) to determine activity and damage indices.
- Validating image analysis software for quantifying corneal nerve damage in Herpes Simplex Keratitis (HSK).
- Improving the understanding of how the immune system recognises and regulates our responses to HSK.